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Sample Sizes for Clinical Trials - CRC Press Book

In rpact particularly, the methods described in the recent monograph of Wassmer and Brannath published by Springer, are implemented and made available for the public. Further developments e.


Specifically, a specific methodology for survival endpoints with adaptation based on surrogates will available. The simulation based evaluation of operating characteristics of adaptive designs are becoming increasingly important, and the package addresses this issue. We developed these simulations for the most relevant types of endpoints continuous, binary, and survival and included the assessment of sample size reassessment strategies based on conditional power, of futility rules and other strategies.

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As adaptive strategies classical group sequential tests, combination tests inverse normal, Fisher's combination test , and adaptive tests based on the conditional rejection probability CRP principle are available. A comprehensive output in form of summaries, graphs and tables is provided. For the analysis and execution of an adaptive trial, all methods provided by the simulation are available.

Sample Size Calculators

Specific results of the adaptive methodology are also available, e. We have highlighted the basic concepts regarding various parameters needed to calculate the sample size along with examples.

Advanced Search. Users Online: An evaluation of the quality of clinical trials in anesthesia.

Innovative Sample Size Methods for Clinical Trials - Webinar

Anesthesiology ; Experimental design and statistical analysis. Can Anaesth Soc J ; Power and sample size calculations in clinical trials from anesthesia journals.

Sample Sizes for Clinical Trials

Anesth Analg ;S Critical appraisal of methodological reporting in the anesthesia literature. Fisher DM.

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Statistics in anesthesia. In: Miller RD, editor. New York: Churchill Livingstone; Determining the sample size in a clinical trial. Med J Aust ; Kadam P, Bhalerao S.

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Sample size calculation. Int J Ayurveda Res ; Basics statistical concepts for sample size estimation. Indian J Anaesth ; Sakpal TV.