Methylation of DNA is associated with a variety of biological processes. With whole-genome studies of DNA methylation, it became possible to determine a set of genomic sites where DNA methylation is associated The Correction to this article has been published in Clinical Epigenetics 10 Content type: Review. Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extre Nevertheless, the association remains controversial and little is The importance of epigenetic alterations in psychiatric disorders is increasingly acknowledged and the use of DNA methylation patterns as markers of disease is a topic of ongoing investigation.
Recent studies Since cell reprogramming and the generation o Eating disorders ED are chronic psychiatric disorders, common amongst women of reproductive age. ED in pregnancy are associated with poor nutrition and abnormal intrauterine growth. Increasing evidence also Authors: Nabila Kazmi, Tom R. Gaunt, Caroline Relton and Nadia Micali. Citation: Clinical Epigenetics 9 Alcohol consumption during pregnancy is a significant public health problem and can result in a continuum of adverse outcomes to the fetus known as fetal alcohol spectrum disorders FASD.
Subjects with FASD s There is increasing evidence for the role of prenatal stress in shaping offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregn Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and Content type: Short report. DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases.
Mitochondrial DNA methylat Authors: Matthew Devall, Rebecca G.
Cerebral white matter hyperintensities WMH on magnetic resonance imaging MRI are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and de Grove, Jan Bressler, Rebecca F. Gottesman, Weihua Guan, James S. Pankow, Eric Boerwinkle, Thomas H. Mosley and Myriam Fornage. Panic disorder PD is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility Epigenetic mechanisms are important for the regulation of gene expression and differentiation in the fetus and the newborn child.
Authors: Anne-Cathrine F.
Citation: Clinical Epigenetics 8 Authors: Katherine A. Sanders, Miles C. Benton, Rod A. Lea, Vicki E. It is hence not surprising that perturbations in its genome-wide distribution, and at particular loci within this Bipolar disorder BD and schizophrenia SZ are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found signifi Staunstrup, Ole Mors, Anders L.
Nielsen, Anders D. Fragile X syndrome FXS is the most common form of inherited intellectual disability, resulting from the loss of function of the fragile X mental retardation 1 FMR1 gene. The molecular pathways associated with Bipolar disorder BD is a severe, familial psychiatric condition. Progress in understanding the aetiology of BD has been hampered by substantial phenotypic and genetic heterogeneity. We sought to mitigate the McCartney, Stewart W. Morris, Nicholas A. Authors: Magdalene C. Jawahar, Chris Murgatroyd, Emma L. Harrison and Bernhard T.
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Citation: Clinical Epigenetics 7 Search all BMC articles Search. Articles Supplements Collections Sections Aging and development epigenetics All other subjects Allergy, immunology and Pathogen Epigenetics Cancer epigenetics and diagnostics Cardiovascular epigenetics Endocrinology and metabolic epigenetics Epigenetic Therapies and Clinical Trials Innovative therapies Neurology and psychiatry Reproductive and Transgenerational Epigenetics Neurology and Psychiatry Epigenetics Section information Section Editors: Jonathan Mill and Moshe Szyf Associate Editor : Jonathan Turner Neurological and psychiatric disease makes a huge contribution to the global burden of disease, but little is known about their underlying etiology.
Citation: Clinical Epigenetics 11 Published on: 21 March Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality The effects of tobacco smoking on epigenome-wide methylation signatures in white blood cells WBCs collected from persons living with HIV may have important implications for their immune-related outcomes, inc Citation: Clinical Epigenetics 10 Published on: 13 December Paediatric Dentistry.
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